Why Children Often Develop Asthma After Antibiotic Treatment at a Young Age

It is known that children are more likely to develop asthma if they have received antibiotics at a young age. However, until now, the reason for this was not understood. Researcher Ben Marsland has discovered that this is due to the disruption of bacteria in our gut. Marsland's Australian research team is now investigating whether this can be addressed with a dietary supplement.

The bacteria in our gut, also known as the gut microbiome, are important for our health. Antibiotics can disrupt these bacteria, as shown by research from Monash University in Melbourne. 

Important Molecule IPA

The early years of life are crucial for developing a strong gut microbiome, says Professor Marsland. This is also important for healthy lungs. A molecule called IPA, made by gut bacteria, helps in the development of lung cells. The molecule provides protection against asthma.

Antibiotics are important medications used to treat bacterial infections. Marsland and his team have discovered that antibiotics deplete the bacteria that produce IPA. This leads to a shortage of the IPA molecule. This makes children more susceptible to airway inflammations, which can lead to asthma later in life.

Treatment Under Investigation

Marsland's team is now investigating whether IPA can be given as a supplement to young children who receive antibiotics. In mice, this has already shown positive results. When young mice receive antibiotics, they remain susceptible to allergies for a longer period. However, when their diet is supplemented with IPA, they recover from these allergies.

The research by Professor Ben Marsland and his team has been published in the journal Immunity. Read the publication here.